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It is apparent to anybody who has read the first four books of the New Testament that one of the teaching tools commonly used by Jesus duri

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ng his ministry was the parable. There are a total of 33 different parables recorded in the books of the Gospel, with 17 of them included i

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

the Gospel of Saint Matthew, 5 in Mark, and 23 in Luke.

But what exactly is a parable?

If you were to consult a modern dictionary for a

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

definition of the word parable you would probably read that a parable is a short allegorical story designed to illustrate or teach some

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ruth, religious principle or moral lesson.

Although this is clearly an accurate definition, it does not give us a full insight into a

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

biblical parable.

To better understand what a parable is, we need to investigate the origin of the word.

The English word parable comes f

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

om the Greek word parabole which literally means to place alongside. So a parable compares one thing to another.

In

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

t="_new" href="http://www.christstudy.net/dic/easton/">Eastons Bible Dictionary this comparison is further explained as being a comp

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

rison of earthly things with heavenly things, making a parable an earthly story with a heavenly meaning. And that is exactly what Jesus

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

did, in his parables he would compare an aspect of everyday life with a truth about the kingdom of God.

But Jesus did not stop there.

On

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

common characteristic of the parables he told was that they would contain a twist which would have been totally unexpected by the original

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

listeners. In fact not only would it be unexpected, it would in many ways contradict or question beliefs they had held for years.

For exam

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ple, a Samaritan - who would be despised by the orthodox Jews and considered as being unworthy of God - ends up as the hero in a story that

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

includes Jewish priests. Wealthy kings whose normal concerns are with their own wealth and power cancel huge debts owed to them by mere ser

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

vants.

This is not your normal behavior, which of course Jesus knew. He also knew that it was because of these strange and unexpected twis

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

s that the parables would grab the attention of those who heard them. You could argue that Jesus was the original shock jock.

Parables als

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

o communicate beyond their original audience. Although rooted in the life and times of Jesus, the teachings found in the parables transcend

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

that culture and speak to us today in images that are still powerful.

The word pictures painted by Jesus in his parables are just as clear

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

today as they were two thousand years ago.

Despite the fact that we may not realize today that a Samaritan was despised by the orthodox J

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ws of his day, we certainly know what a good Samaritan is. Many of us have either been one or have been grateful to have been helped by one

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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