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Over the past few years gas prices seem to always be in the news. In one week they are extremely h

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

igh and the next they are extremely low. This volatility in gas prices is not a positive trend fou

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

our country as we are trying to increase stability and then in turn increase our economic growth.

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

Unfortunately, these bouncing prices leaving the U.S. behind other countries as our growth rate i

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

2 - 2.5% and not the 5% expected globally.

In March gasoline prices rose 10.6% making it more ex

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

pensive to commute to and from work. This expense eats up any increases in income that may have be

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

n experienced during the past month. Furthermore, it costs companies more to transport their produ

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

cts, send mail, and get supplies. This increase in cost in transportation and resources will again

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

be sent back to the consumer who experiences further income loss for basic necessities.

Thus a su

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

bstantial and sustain increase in oil prices has a compounding effect on society and the economy.

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

eating costs are higher, food costs which use gasoline in tractors are higher, product costs are h

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

igher, the cost of war which uses lots of fuel goes up, less jobs are produced and things cost mor

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

money across the board.

The good news is that when checking on the price of food and clothing (b

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

asic necessities) it was found that clothing costs reduced slightly while food rose only slightly.

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

In other words, the higher cost of fuel is not reflected in other product which means it is not ye

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

t damping the economy. It can be said, however, that the rise in fuel cost is one of the major con

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ributors to the rising of inflation and loss of realized income.

The faster the Country can devel

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

op alternative sources of fuel that are both sustainable and cost effective the less reliance on o

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

l. The less reliance on oil the less likely the price of oil will bounce around and affect the eco

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

nomy. A more stable economy means a better chance of sustained growth in GNP, jobs and investments

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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