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Installing FaxMaker has always been pretty routine for me, except of course when I did it for myself. Now being a frugal kind of guy, I decided to make due with an antique (relatively speaking)

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

HP Pavilion 7955 tower running XP Pro, and 512 MB RAM.

There are essentially two methods of installing FaxMaker. One way if you are adding FaxMaker to an Active directory domain with Exchange,

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

the other if you are in a peer to peer network called SMTP mode. Since FrugalBrothers is a SBS 2003 shop, I chose the former install.

First I must confess, I had forgot to pre-install MS Outloo

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

k on the machine, This is necessary for conversion from TNEF to MIME. Once I installed Outlook and made a connection to the Exchange Server, I was ready to proceed.

I had copied the FaxMaker in

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

staller to the local disk from my network share. After running setup, FaxMaker asked me for an Administrators account to start the service. I next completed the setup wizard, making myself the F

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

axMaker administrator.

One thing important to remember is to install IIS and SMTP services on the new fas server machine, unless you are installing it on an existing Exchange Server. I don't re

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

commend that you do however. Faxing is resource intensive, especially if a lot of conversions are going on.

Also if you are using a fax modem, remember to install windows fax services, so GFI c

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

an use the windows driver. I went another route and I'll explain why in a bit. I am waiting to purchase a new 4 port Quattro MainPine board in the next few months, so for the purposes of testing

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

FaxMaker and putting it through its paces, I used the built in modem on the old Pavilion, a Lucent WinModem.

The install wizard will attempt to identify the correct modem on its on, or if you

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

are running the windows fax service, will automatically detect the windows drivers. I choose the windows driver.

The installer runs a test, in which it tests the SMTP MTA, and the first time, I

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

t was successful and email a message to me saying so. I then opened the GFI Configuration tool and was greeted by and error message telling me that my configuration database was corrupt.

The c

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

onfiguration file is an Access database, in the faxmaker subdirectory. I checked permissions and they were ok. I tried a reinstall, but I got some new errors this time. First when using the wind

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ows fax drivers, I failed the MTA test, it just kept timing out. This time I chose, to use the GFI driver, and I passed the MTA test. When I launched the FaxMaker configuration, it opened withou

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

t complaint.

The next step is pretty straight forward, I needed to install the GFI connector on the SBS Server. Now I couldn't find this anywhere in the user manual, but you must make a change

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

to the settings of the connector, and on the general tab, change the smarthost from the name of your Exchange Server to the FaxMaker SMT server (in brackets)

Installing the client software give

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

s you multiple options as well. You can choose an Outlook messaging only form, or the FaxMaker New Message form or a combination of both. I installed both on my workstation.

After some configur

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ation on the server side, I was ready to send a test fax. I fired up Outlook, selected a contact fax number and attached a word document. Nothing happened! after about an hour of troubleshooting

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

, and even calling GFI support (it was late Friday, and I appreciate Ben at GFI helping me out) I still couldn't send a fax.

The very last thing I tried was check windows firewall on the FaxMak

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

er Server And enabled port 25, for inbound and outbound and all of a sudden my test faxes started going into queue, and FaxMaker was happily chugging away. I guess the hours I spent meditating p

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

aid off.

FrugalBrothers.com Phone: (260)918-3188 Cell: (260)414-5317 E-mail: bruce.naylor@frugalbrothers.com www.frugalbrothers.com

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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