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Top Adding - Two of Us
SOMEWHERE in the junkyard that I call my home office, there’s an issue of Fortune magazine circa August 1991. On the cover are two of the most recognizable faces in the computer industry, even today: Micros
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
oft’s Bill Gates and Apple’s Steve Jobs.
In the cover story, Gates, then only 35, and Jobs, 36, spoke of the future of the personal computer. To put things in perspective, Windows 95 was still four years a
In the cover story, Gates, then only 35, and Jobs, 36, spoke of the future of the personal computer. To put things in perspective, Windows 95 was still four years a
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
way, and Jobs had been kicked out of Apple and struggling with his workstation company, Next. The iPod was still 10 years away. It was, as far as I can tell, the last time the two industry icons were interv
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
ewed together, until the All Things Digital 5 conference last May 30—or some 15 years later—organized by the venerable Walt Mossberg and Kara Swisher of the Wall Street Journal.
A copy of the session is av
A copy of the session is av
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
ailable free as streaming video on the D5 site (http://d5.allthingsd.com) or as one whole MP4 file from the Apple iTunes store (almost 1 gigabyte). An audio file (83.3 megabytes) is more manageable. In any
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
ase, it’s well worth listening to these industry pioneers talk about the past, present and future of computing.
The video is also an interesting study in contrast, not only between Gates and Jobs today, bu
The video is also an interesting study in contrast, not only between Gates and Jobs today, bu
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
t between how they viewed the industry, then and now.
In 1991, the issue of competition—and Microsoft’s domination of operating systems—was clearly on Jobs’ mind. When the discussion turned to pen computin
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
g and the pioneering Go Corporation, Jobs predicted—correctly as history shows—that the company would be crushed. That prediction came true when the company closed in 1994 in the face of competition from Mi
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
rosoft’s Pen Services for Windows.
In 2007, however, an older Jobs talks of acceptance. “You know, we don’t have a belief that the Mac is going to take over 80 percent of the PC market,” Jobs says at one p
In 2007, however, an older Jobs talks of acceptance. “You know, we don’t have a belief that the Mac is going to take over 80 percent of the PC market,” Jobs says at one p
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
oint. “You know, we’re really happy when our market share goes up a point and we love that and we work real hard at it, but Apple’s fundamentally a software company and there’s not a lot of us left and Micr
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
soft’s one of them.”
Curiously, 15 years after the Fortune Magazine interview, Gates is still talking about pen computing, calling himself an “unrepentant” believer in the tablet form factor.
“I think you
Curiously, 15 years after the Fortune Magazine interview, Gates is still talking about pen computing, calling himself an “unrepentant” believer in the tablet form factor.
“I think you
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
’ll have voice [activated commands]. I think you’ll have ink. You’ll have some way of having a hardware keyboard and some settings for that,” Gates says of the future tablet PC.
While Jobs expects computer
While Jobs expects computer
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
s to evolve and become more mobile, he also talks about an explosion of “post-PC” devices such as the iPod and iPhone, where people “are inventing things constantly.”
Neither Gates nor Jobs, however, see a
Neither Gates nor Jobs, however, see a
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
end to the general-purpose personal computer.
Unlike in 1991, if there were any animosity between the two, it did not show. In 2007, Gates and Jobs appeared like old friends, sharing reminiscences and the
Unlike in 1991, if there were any animosity between the two, it did not show. In 2007, Gates and Jobs appeared like old friends, sharing reminiscences and the
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
occasional jibe, but all in good humor.
“His mother likes him,” Gates quips about the PC guy in Apple’s now-famous “I’m a Mac” commercials that poke fun at Windows computers. This was all entertaining an
“His mother likes him,” Gates quips about the PC guy in Apple’s now-famous “I’m a Mac” commercials that poke fun at Windows computers. This was all entertaining an
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
informative, but Mossberg, Swisher and the other participants who joined the short question-and-answer session afterwards, missed a great opportunity to ask Gates and Jobs about how they see free and open
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
source software will affect the industry.
Mossberg may not see it yet—perhaps he has not installed a user-friendly Linux distribution such as Ubuntu--but there is a sea-change coming that will see more com
Mossberg may not see it yet—perhaps he has not installed a user-friendly Linux distribution such as Ubuntu--but there is a sea-change coming that will see more com
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
panies and individuals, especially in the developing world, choosing free and open source software over proprietary solutions such as those offered by Microsoft and Apple. It’s a pity nobody in the conferen
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
e thought of asking Gates and Jobs about it.
As you might expect, while both men are excellent communicators, it was Jobs who struck a chord that resonated with his generation. Summing up his relationship
As you might expect, while both men are excellent communicators, it was Jobs who struck a chord that resonated with his generation. Summing up his relationship
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.
Companies that provide selfless information through particip
Companies that provide selfless information through particip
with Gates, he quoted a 1969 tune entitled Two Of Us: “There’s that one line in that one Beatles song, ‘You and I have memories longer than the road that stretches out ahead.’ And that’s clearly true here.
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
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