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True story #1: I was in an ill-fated MLM venture about two years ago. One of my former upline l

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

eaders called me the other day with another fabulous “opportunity”. I could be in my own travel

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

business for just a few hundred dollars, plus about 50 bucks a month. Company pays commissions

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

mostly on these fees, and you only make pennies on the actual booking of travel services (Hey,

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

what’s that ticking sound? Is something burning?).

Anyway, nice lady, but I wouldn’t join that

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

thing in a million years. Told her so nicely, tried to let her down easy. She didn’t hear a wor

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

d I said. She had 101 reasons why I should jump in anyway, mainly because SHE loved it.

I smil

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ed and shook my head, still turning her down. I’m not looking for an “opportunity”. She wants t

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

stay in touch with me, because that’s what you’re supposed to do when somebody turns you down,

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

right? So I say OK, and goodbye.

True story #2: Last night, phone rings. Someone wants to tal

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

to me about my business. Great! “How’d you get my number?” I ask. “Why, that’s one of the tri

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

cks I’ll show you when you get on this conference call!” He dropped the name of a very big guru

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

in the industry who has admittedly never built a MLM downline, but getting on his call is gonn

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

make me rich! I declined, so this idiot says to me, “OK, it’s your money!”

Yes. It is. And th

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

at’s how I’m gonna keep it.

At least the first lady was speaking from her heart. The second gu

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

was reading from a script! Poor schmuck was so let down when I refused, I could hear it in his

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

voice. I could feel it. His “system” isn’t working. He’s disappointed.

Maybe one day these pe

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ople will learn. You can’t be successful persuading people who don’t want to be persuaded. They

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

know what you’re offering, or they don’t. They care, or they don’t care. If they don’t, there’s

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

nothing else you can do but keep it moving. Make it easy on yourself--- find the ones who care

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Getting a refinance done is a huge financial transaction. Here are items you should do to get yourself a good deal.

Here are a few tips on ways to refinance and consolidate your first and second mortgage.

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