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There are a number of reasons being discussed by booksellers all over the Internet. Some of the reasons I have read include:

1) A des

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ire by some to curtail the profiteers and assure that there are some good books left when the sale opens to the general public.

Certai

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ly, this hinders the online bookseller and limits the number of books that he/she is able to check, but I do not think this is the reas

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

on.

2) Another hypothesis I have heard is that booksellers rummaging through the books and scanning them leave the unwanted books in d

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

sarray, thus making more work for the volunteers to straighten out the mess, but I do not think this is the reason either.

The time it

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

takes to straighten out tables of books after a couple hundred booksellers have finished rummaging around is probably not any longer t

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

an straightening out after a few thousand people during the "open to the public" period.

3) There are also some that believe the cashi

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ers do not like ringing up hundreds of books for booksellers,

This does not make any sense because it is a lot easier to make one sale

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

of hundreds of books to one buyer than to ring up two books for hundreds of customers, so I do not think this is the reason.

4) The vo

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

lunteers and helpers at the book sales are jealous of booksellers coming in and buying up all the good books to make a profit on them.

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

I do not doubt that there a people working the book sales and attending them that are jealous of dealers coming in and buying up the va

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

uable books, and this probably does play into the decision to ban scanners, but I do not think it is the primary reason either.

I beli

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

eve the book sale organizers are genuinely concerned about safety and potential litigation. If you have ever been zapped in the eyes b

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

a careless bookseller with a total disregard for where he/she is pointing their scanner, you know exactly what I mean. You will see sp

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ots and/or floaters for a good half hour. If exposed to a direct laser of the intensity of my HP 5P (class II) scanner, I do not doubt

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

that you would suffer some permanent eye damage.

I was personally zapped accidentally by someone using their laser scanner and I could

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

not read ISBN's or the screen on my PDA for almost 45 minutes. I believe laser scanners are being banned from book sales because of l

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ability issues; and with our society being so focused on taking someone to court; the book sale organizers do not want to risk being he

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ld responsible for the actions of a careless bookseller. As obnoxious as some of the booksellers I have seen can be, I would not put i

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

past some of them to intentionally zap me if for no other reason than to temporarily give them an edge in buying while my eyes recover

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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