Top Adding - Real Estate

Consumer Price Index (CPI): Most of commercial real estate leases have annual rental increase that is based on

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

the CPI. As an investor you should know what it is. The CPI is a measure of the average change over time the prices

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

paid by urban consumers for goods and services. In a sense it is the measure of inflation as experienced by urban c

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

onsumers. So as an investor/landlord, you want the rent increased to catch up with inflation. The US Department of La

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

or, Bureau of Labor Statistics collects data from 87 urban areas in the US which cover about 87% of the population.

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

The data is published each month and available from the website http://stats.bls.gov. Although there is only one nam

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

e for the CPI, there are various numbers: US city average, Northeast urban, Midwest urban, South urban, West urban,

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

as well as 14 major local areas. So you need to know which number is defined in the lease so you can correctly calcul

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ate the rent increase. For example, the CPI for US city average was 190.9 in Oct 2004 and is 199.2 in October 2005.

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

This reflects a 4.3% increase for one year. So if the rent from October 2004 to September 2005 was $1000/month and t

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

e lease says the rent is increased based on the CPI for US City average then the new rent from October 2005 to Sept

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ember 2006 will be $1043 a month or 4.3% higher.

Cost of Living Index (COLI): COLI is a number that i

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ndicates the relative cost of living in various cities in the US with 100 being the average. You could obtain the i

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ndexes for various cities from http://www.infoplease.com/ipa/A0883960.html. The COLI for San Francisco is 177 while i

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

’s only 97.2 for Atlanta. This means it costs 82% more to live in San Francisco than Atlanta.
As an investor, y

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ou often review median income in the demographic data for the area where the property is located. You prefer to inves

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

t in a more affluent area. The median income alone does not give you a whole picture. You will have a better perspe

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

tive if you adjust the income based on the Cost of Living for the area and then compare with the median for the area

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

you know. For example if the median income is $80K a year in Alpharetta in Atlanta metro area, it would be equivale

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

nt to $145,600 in San Francisco. With this adjusted number you know that Alpharetta is a very affluent area.

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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