Top Adding - Real Estate

There are many different kinds of properties and many different places where you could be looking to purchase, but in every place there should be certain things in common. It is my goal here to provide you with some basic information that may help you to k

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

now what to look for (and what to check) before you buy a property overseas.

No duplicate title or claim on the property
Every country will have a different name for the organization which has information on who has legal title to the

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ouse/condo/ land about which you are inquiring. In the United States the county in which the property resides has information about the legal owner of that property. In Costa Rica, the Registro Nacional has all the information about who has legal title to

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

a property. Each property is assigned a ‘Folio Real’ which is a unique number, and the current owner as well as the ownership history is recorded in the Registro Nacional every time there is movement on a property. If you are buying property in Costa Rica

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

you need to make sure that the person or enterprise selling you the property is actually the owner. You can verify this yourself with the Registro Nacional in San Jose, or you can use a reputable attorney to investigate the property. In either case, you

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

r your attorney must check the Registro Nacional.

Water Issues
When buying property in Costa Rica you MUST make ABSOLUTELY SURE that water will not be an issue. This is especially true if you are interested in buying an undeveloped pa

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

cel of land. The community you are looking in will have what Costa Rican’s call an asada… A&A. these are small, local groups which control water rights. You need to check with the A&A for your area to find out who is or will be supplying water to the pro

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

erty you are interested in. If you do not speak Spanish, contact a reputable attorney for this specific purpose. Do not simply take the seller’s word for it that the property has water. They might be as honest as can be, but they could be mistaken, too.

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

You must know for a fact that the property has water or where the water will come from.

The Development, House or Condominum complex has obeyed all the survey and engineering laws.
I have heard and seen cases where some developments we

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

e built encroaching on a public street or where a condo swimming pool was built on an adjacent lot not owned by the developer. You can easily make sure that the Condo you are buying has been signed off by the Colegio de Ingenieros, the architect and the mi

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

isterio de Salud before buying. If the developer cannot show you the signed off documents, then think twice before buying. Do not just assume everything is ok simply because the development is pretty or costs a lot of money.

Construction is of Go

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

od Quality
Make sure that you know how the building was built. This is important because there are many fly by night developers who buy cheap materials and skimp on things like rebar because it’s costly. You need to ask what number of rebar t

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ey used and how much has been used. You need to know if the walls are concrete or drywall. You need to know if the structure is concrete or if its metal beam. You need to know if the development has a seismic foundation (in earthquake prone areas) or if

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

t’s built to hurricane standards (in a hurricane prone area). Check things like wall thickness between units, how many and where are the supporting beams. Do not just pay attention to pretty little details like paint or cabinet knobs. Those do not matter

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

Access to Telephone and Internet
Unless you want to get away from it all and not have a phone or internet, it is important that the property you buy comes ready for phone service and internet service. A lot of times you will have tro

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ble getting either service, most likely because the provider doesn’t provide service in that area or simply because it’s a government run monopoly that is grossly inefficient. However, your job is to make sure that the property is CAPABLE of receiving thes

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

two services.

If possible, buy a furnished unit or house
The reason I’m suggesting this is because in most countries outside the United States, your supply is limited to some degree. In Costa Rica, you have a good selection of nice f

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

rniture, but its not as easy as jumping in your car, driving 3 blocks to the nearest furniture store and finding exactly what you like at a reasonable price. In Costa Rica, you will have look, and that takes time and effort. Time and effort are in short s

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

pply if you come only for a few weeks to vacation and have fun. There are many fine furniture stores, but there’s always something. The furniture is nearby, beautiful but way too expensive. Or the sofa you like is in San Jose, the table is in Sarchi, the

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

beds are in Palmares and the rest of it is imported from Bali, but costs a lot of money. My advice is buy a home that is already furnished. If it isn’t furnished, make arrangements with the seller to furnish it. You will spare yourself a LOT of heartache

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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